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Health library/Crigler-Najjar syndrome

Rare liver disorders / RARE CONDITION

Crigler-Najjar syndrome

Also known as: Familial nonhemolytic unconjugated hyperbilirubinemia, Hereditary unconjugated hyperbilirubinemia

Crigler-Najjar syndrome impairs processing of bilirubin in the liver. Severe bilirubin accumulation can threaten the brain, especially early in life.

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What you may notice

Symptoms can overlap with other conditions and vary between people.

  • Marked jaundice
  • Yellow eyes
  • Neurological changes if bilirubin rises severely

Understanding care

Clinical care may include prompt specialist bilirubin assessment and ongoing liver-focused management. A qualified clinician decides which investigations and options fit the individual situation.

When to seek help

New or worsening jaundice, especially in an infant with poor feeding, needs prompt assessment. Marked drowsiness, seizures, vomiting blood or collapse requires emergency care.

For severe breathing difficulty, collapse, suspected stroke, or another emergency, call local emergency services immediately. In India, call 112.

Read the medical sources

These sources support the educational article and offer more detail.

Educational reading · Updated 6 October 2026

Prepared from the linked sources. This summary has not had an independent clinician review. A qualified clinician can assess symptoms and explain which information applies to you.

A child and a caring grown-up reading a picture book together

LITTLE PEOPLE. BIG FEELINGS.

It’s okay to have
a lot of questions.

A doctor visit or an unfamiliar health word can feel scary. You can ask a trusted grown-up to help you understand, one small question at a time.

01

Say how you feel.

“I feel worried” is a good place to start.

02

Ask for simple words.

“Can you explain that in a way I understand?”

03

Bring someone you trust.

A caring adult can help you ask and listen.

For children and their grown-ups. This illustration explains a conversation, not a diagnosis. An adult should seek qualified care for a child who is unwell.

Crigler-Najjar syndrome — First AID health library